TORCH Diagnostics Solutions

TORCH is an acronym for a group of infectious diseases that can cause severe complications during pregnancy, potentially leading to miscarriage, birth defects, or developmental issues in the fetus. The test detects specific antibodies (IgG and IgM) in the mother's blood to determine her immune status and identify recent or active infections that pose a risk to the fetus. It is a crucial prenatal tool for identifying infections that can harm the fetus, enabling informed clinical decisions.

Application Scenarios

Features of Getein TORCH Diagnostics Test Kits

²  Suitable for different types of analyzers

²  Simple operation, easy to use

²  Need only 10μL sample

²  Long shelf life: 36 months

Getein TORCH Solutions:

TORCH Markers

Detection Platforms

T：Toxoplasmosis

Toxoplasmosis is an infection with a parasite called Toxoplasma gondii. People often get the infection from eating undercooked meat. You can also get it from contact with cat feces. The parasite can pass to a baby during pregnancy.

Most people infected with the parasite do not have symptoms. Some people get flu-like symptoms. Toxoplasmosis during pregnancy may cause miscarriage and birth defects.

R:  Rubella

Rubella is an acute respiratory infectious disease. Typically, infected individuals present with mild clinical symptoms, primarily including skin rash, low-grade fever, and localized lymphadenopathy. As the rubella virus is a teratogenic pathogen, infection in susceptible pregnant women—those without protective antibodies—during early pregnancy can lead to miscarriage, stillbirth, or the birth of a child with Congenital. It is recommended that all women who are planning a pregnancy or undergoing assisted reproductive technology be screened for RV-specific IgG and IgM antibodies.

C:  Cytomegalovirus

Cytomegalovirus is one of the most common pathogens responsible for congenital infections worldwide. The virus can persist latently in various bodily fluids such as blood, urine, and breast milk, and is transmitted through multiple routes. Individuals with compromised immune function are highly susceptible to CMV infection, such as those with HIV infection, organ transplant recipients, individuals undergoing pregnancy and childbirth, and those with malignant tumors.

H： Herpes simplex 

Herpes simplex virus is a widespread viral infection that affects millions of people worldwide. It belongs to the Herpesviridae family and is classified into two main types: HSV-1, which is primarily associated with oral herpes, and HSV-2, which is more commonly linked to genital herpes. Many individuals infected with HSV are asymptomatic, serological testing can detect these carriers, differentiate between HSV types, and provide strong evidence for clinical diagnosis.

References：

[1] Uboldi AD, Wilde ML, Bader SM, Tonkin CJ. Environmental sensing and regulation of motility in Toxoplasma. Mol Microbiol. 2021 May;115(5):916-929.

[2] Teimouri A, Mohtasebi S, Kazemirad E, Keshavarz H. Role of Toxoplasma gondii IgG Avidity Testing in Discriminating between Acute and Chronic Toxoplasmosis in Pregnancy. J Clin Microbiol. 2020 Aug 24;58(9):e00505-20.

[3] Vauloup-Fellous C. Standardization of rubella immunoassays. J Clin Virol. 2018 May;102:34-38.

[4] Shang Z, Li X. Human cytomegalovirus: pathogenesis, prevention, and treatment. Mol Biomed. 2024 Nov 25;5(1):61.

[5] Canfield D, Gabby L, Vaziri Fard E, Gyamfi-Bannerman C. Cytomegalovirus in Pregnancy. Obstet Gynecol Clin North Am. 2023 Jun;50(2):263-277.

[6] Davis NL, King CC, Kourtis AP. Cytomegalovirus infection in pregnancy. Birth Defects Res. 2017 Mar 15;109(5):336-346.

[7] Oliveros A, Fonseca PA, Pérez CA, González JM. Disseminated herpes simplex virus infection in pregnancy. Biomedica. 2024 Nov 6;44(4):460-467. English, Spanish.

[8] Patel R, Kennedy OJ, Clarke E, Geretti A, Nilsen A, Lautenschlager S, Green J, Donders G, van der Meijden W, Gomberg M, Moi H, Foley E. 2017 European guidelines for the management of genital herpes. Int J STD AIDS. 2017 Dec;28(14):1366-1379.