Superior Performance Makes MAGICL 6000 the Preferred Choice
Getein's MAGICL 6000 is a chemiluminescence instrument equipped with a whole blood test module, which has been widely praised by end users worldwide for its small size and fast measurement speed. Compared to traditional laboratory detection methods represented by Sysmex, the MAGICL 6000 HCT module continues to perform consistently and demonstrates excellent correlation in several cardiac markers, showing a great potential for clinical application. The accuracy and precision of analyte concentrations measured in whole blood by chemiluminescence immunoassay (CLIA) have been significantly affected by erythrocytes, which leads to poor application of whole blood CLIA in clinical practice. However, the ratio of the packed red blood cell volume to the total volume of blood, known as hematocrit (HCT, %), provides critical information about a patient's health status that helps physicians to diagnose and treat various medical conditions, ailments, and diseases [1–3]. In some emergency situations, if chemiluminescence immunoassay can directly detect whole blood samples, it can significantly reduce the detection time and get earlier and faster treatment for patients. 1. Paper Overview The paper was published on December 21, 2022 by Dr. Huan Zhao, Southeast University in the journal Biosensors. Biosensors is an international, peer-reviewed, open access journal and the Impact Factor is around 5.743. It compares the correlation between the MAGICL 6000 partial project for the determination of various hematocrit levels in human blood from 0% to 65% by conventional assays and conventional laboratory methods. For whole blood samples, the MAGICL 6000 readout subsystem measures HCT at each sample. the HCT correction is calculated by a software algorithm, and finally, the results for whole blood are accurately reported. The results showed a correlation around 0.9885. Comparison studies using whole blood samples and corresponding plasma samples showed that the square of the correlation coefficients of cTnI, MYO, CK-MB, and NT-proBNP were increased to 0.9992, 0.9997, 0.9996, and 0.9994, respectively, showing a great potential for clinical application. 2. Paper Methods To address such industry pain points, a chemiluminescence biosensing optical platform for blood hematocrit (HCT) analysis using MAGICL 6000 (Getein Biotechnology, Nanjing, China) was designed. The established HCT detection method for human blood samples reported in this paper requires only 0.1 µL of sample loading without any sample pretreatment, which is much easier than the traditional method. The biological principles of the procedure are as follows: a certain volume of whole blood samples was lysed with the denaturing agents containing 20 mmol/L CTAB and 1 mol/L ammonium chloride (no pretreatment was required for serum or plasma), and then incubated at 37 ℃ with microparticles coated capture antibodies and acridinium-labeled detection antibodies. The blood...
