IL-6 Fast Test Kit
(Immunofluorescence Assay)
Intended Use
IL-6 Fast Test Kit (Immunofluorescence Assay) is intended for in vitro quantitative determination of interleukin 6 (IL-6) in human serum, plasma, whole blood and peripheral blood samples. IL-6 is an early marker in acute inflammation and this test can be used as an aid in the inflammatory diseases.
About IL-6
IL-6 is a cytokine that functions in inflammation and maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response. This classical responsiveness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80-kDa cognate Alpha-chain (IL-6R Alpha), and a ubiquitously expressed 130-kDa Beta-chain receptor (gp130) which acts as the universal signal transducing element for all IL-6 family cytokines.
Many different cells are capable of IL-6 synthesis including monocytes/macrophages, fibroblasts, endothelial cells, keratinocytes, mast cells, T cells and many tumor cell lines. In vivo and in vitro, IL-6 acts as a differentiation factor for B cells and an activation factor for T cells.
IL-6 is a potent growth factor of different human myelomas and is active in concentrations less than 10 pg/mL. IL-3 and IL-6 show in vitro synergistic effects in the differentiation of hematopoietic progenitor cells. Elevated IL-6 serum or plasma levels may occur in different diseases including sepsis, autoimmune diseases, lymphomas, AIDS, alcoholic liver disease and in patients with infections, or transplant rejection.
Specifications
|
Test Item |
Sample |
Detection Range |
Storage Condition |
|
IL-6 |
P/S/WB/ peripheral blood |
1.5-4000.0 pg/mL |
4-30℃ |
|
Method |
Test Time |
Cut-off Value |
Shelf Life |
|
Immunofluorescence Assay |
15 min |
7.0 pg/mL |
24 months |
Applicable Device
Getein 1100 Immunofluorescence Quantitative Analyzer
Getein 1160 Immunofluorescence Quantitative Analyzer
Getein 1180 Immunofluorescence Quantitative Analyzer
Getein 1200 Immunofluorescence Quantitative Analyzer
Getein 1600 Immunofluorescence Quantitative Analyzer
Clinical Application
1. As an aid in the early diagnosis of inflammation.
2. As an aid in the prognostic of sepsis.
3. As an aid in the monitoring of Immune system disorders and patients with infections, or transplant rejection.
4. As an aid in the diagnosis of autoimmune diseases, lymphomas, AIDS, alcoholic liver disease.
